Buy Ksalol (Alprazolam)
Ksalol is the brand name for Alprazolam. Alprazolam is a intermediate acting 1,4-benzodiazepine. It is primarily used as anti-anxiety. It acts on the CNS and produce sedation, sleep and inhibition of anxiety. It is also used for sleep disorders and premenstrual syndrome. It also appear to have anti-depressant effect. Benzodiazepines are most widely used anxiolytic drugs and have replaced barbiturates and meprobamate because of their efficacy and safety.
Alprazolam can produce potentially life-threatening effects which include respiratory depression and blood dyscrasias. Common side effects are agitation, sleepiness, and lack of coordination. Prolonged use of this can cause tolerance, dependence and withdrawal effects, if stopped abruptly. It should not be used in pregnancy and lactation as it can cause harmful side effects. Benzodiazepines acts by binding to specific site on GABA receptors and increase the frequency of Cl- channels which in turn lead to membrane hyperpolarization and CNS depression.
History of Alprazolam
Sedatives and Narcotics have a long been used for the purpose of medication and leisure, starting with alcohol which is foremost and original sedative in the history. Paraldehyde, bromides, chloral hydrates were created during the 1800s, trailed by barbiturates and meprobamate in early twenties. These substances are restricted by their high potential for misuse and reliance and their possibly deadly results of overdose.
Alprazolam was manufactured in 1971 and approved for medical use in the United States in 1981. Alprazolam is a Schedule IV controlled substance and is a common drug of abuse. It is available as a generic medication. In 2019, it was the 41st most commonly prescribed medication in the United States, with more than 17 million prescriptions.
However, with time it came into attention that due to its high efficacy, it can be abused. The study named “misuse of alprazolam” favors the potential of abuse and dependence of alprazolam and emphasizes on reinforcement of monitoring for this medication. This medication is categorized as SCHEDULE IV by Drug Enforcement authority (DEA), which means it is controlled substance but is comparatively less addictive. According to the research, Non medical use of alprazolam is comparable to the Ksalol. This data needs to be transferred to health professionals.
Before you go ahead and buy Ksalol online there are many factors one needs consider. We hope this study will help you make an informed decision.
Uses of Alprazolam
ksalol is primarily used for anxiety and sleep disorders. It acts on the CNS and produce sedation, sleep and inhibition of anxiety. It is also used for sleep disorders and premenstrual syndrome. It also appear to have anti-depressant effect. Benzodiazepines are most widely used anxiolytic drugs and have replaced barbiturates and meprobamate because of their efficacy and safety Benzodiazepines are most widely used anxiolytic drugs and have replaced barbiturates and meprobamate because of their efficacy and safety.
Ksalol used for Panic Disorders
Ksalol is used to treat panic disorders. Panic attacks are sudden episodes of severe fear that has physical manifestations, when apparently there is no danger. In Australia, its use for panic disorders was RECENTLY limited due to the concerns regarding tolerance, abuse and dependence. But in US, FDA approved the drug for use in panic disorders.
Ksalol used Anti-anxiety
Ksalol (Alprazolam) is used for anxiety and panic disorders. Anxiety is an upsetting condition of strain, worry, or uneasiness (a dread that appears to emerge from an obscure source). Anxiety disorders are the most common mental disturbances. Anxiety causes both psychological symptoms and physical symptoms. The physical symptoms of severe anxiety include Tachycardia, sweating, trembling, palpitations, muscular tension, tightness in the abdominal region, restlessness, fatigue, inability to catch ones breath. It involves sympathetic activation. Episodes of mild anxiety are common life experiences and do not require any treatment. However, the symptoms of severe, persistent, debilitating anxiety may be treated with anti-anxiety drugs such as benzodiazepines which include Alprazolam.
It is used to treat anxiety related to depression. It shouldn’t be used for long period of time as it causes chronic depression if used for prolonged period.
Caution: It should not be used to alleviate the normal stress of everyday life. They should be reserved for continued severe anxiety, and should only be used for short periods of time because of their potential of causing addiction.
How to take Ksalol
Oral (Tablets and liquid form)
Ksalol v/s Valium:
For anxiety, Ksalol (alprazolam) can be used for immediate relief of panic attacks and seizures, but is not intended for long-term management. Valium (Ksalol) is effective for occasional or short-term use for anxiety and muscle spasm but not for minor anxiety of everyday.
According to a research, Valium is more effective than ksalol for the treatment of anxiety but overall difference is not significant.
Both cause dependence and are equally addictive controlled substances and are categorized as Schedule IV medications by the Drug Enforcement Administration (DEA). Both are equally misused.
Ksalol v/s Tegretol
Ksalol is alprazolam and tegretol is carbamazepine. Carbamazepine binds to voltage-dependent Na+ channels (prolong the inactivated state) and prevents further entry of Na+ Ions into the neuron.
Ksalol can be used to control seizures but not primarily used for this. Tegretol has little effect on anxiety however ,it is used to stabilize mood.
Ksalol causes dependence and has potential for abuse while no evidence of abuse is found for tegretol. It cannot cause physical or psychological dependence. Also tegretol is well tolerated as compared to ksalol.
Ksalol v/s Ativan(lorazepam)
Ativan is lorazepam. Both ksalol and Ativan are benzodiazepines. Both are used for anxiety and epilepsy. Ksalol (alprazolam) can be used for status epilepticus but Ativan is the first line drug according to treatment guidelines for status epilepticus.
For anxiety, Ksalol can be used for immediate relief of panic attacks and seizures, but is not intended for long-term management. Helps you relax. Ativan (lorazepam) is an effective medicine for occasional or short-term anxiety.
Depression of Central Nervous system:
Using Ksalol can cause decrease in motor skills, drowsiness and decrease in cognition .Cognitive activities that require learning and recalling of previous knowledge is impaired. It can also effect the decision making power of a person. Routine work can be severely affected. Ataxia can also occur on higher doses. Activities requiring fine motor functions can be impaired.
The dosage of alprazolam should be reduced in elderly, as they are more susceptible to drugs that case psychomotor dysfunctions.
Depression of Central Nervous system:
When used for prolonged period of time, ksalol can cause dependence. In such cases, withdrawal effects can occur when drug is suddenly stopped. As ksalol is long acting drug so withdrawal symptoms occur slowly within three weeks and are less lethal. Withdrawal effects include
- unpleasant dreams
- tremors, anorexia
- sleep abnormalities
- Convulsions can occur, in severe cases.
Addiction of ksalol is more common in people with personality disorder and previous history of sedative or alcohol abuse.
Tolerance can occur with chronic use of ksalol. Tolerance is the decrease in the responsiveness, occurs when drugs are used chronically. Thus to maintain the pharmacological action of the drug ,dose of the drug have to be increased with the passage of time.
Long term use of benzodiazepines for insomnia is not recommended because of tolerance, dependency and hangover effects, but these drugs are ideal for occasional use by air travellers, shift workers etc
Hangover effects are headache and residual drowsiness on waking. Due to the prolonged effect of Ksalol, it has strong hangover effect, so their long term use should be discourage.
Floppy baby syndrome:
Usage of benzodiazepines during labor may cause respiratory depression and hypotonia known as floppy baby syndrome in newborn and even the withdrawal effects can occur in new born.
Overdose of alprazolam can seldom occur and can cause respiratory and cardiovascular depression. Coma can occur. Other symptoms may include:
• Bluish-colored lips and fingernails.
Overdose can be reversed effectively by Benzodiazepine antagۭoniۭۭۭst named flumazenil. It can reverse the Central Nervous system depression produced but over dose but is not efficacious against respiratory depression.
It can be given intravenously in the dose of 200micro gram initially in 15 seconds, then 100 micro grams at 1 minute intervals.
It should be used with caution in patients with aspirin hypersensitivity as it may induce allergic reaction۔
Other Side effects:
Other symptoms include:
Phlebitis, changes in libido, pain at injection site poor appetite, constipation and hematuria are some other side effects.
Ksalol should be used with caution in patients with respiratory diseases and in patients with hypersensitivity. In patients with depression, give least amount of drug.
It should be used with caution in patients with myasthenia Gravis.
Can I take Ksalol (Alprazolam) if I am pregnant or breastfeeding?
No, Alprazolam is harmful for the baby both during pregnancy and breast feeding. Alprazolam is classified in FDA pregnancy category D, which means there is possible risk to fetus. It has the potential to cross the Placental barrier in pregnancy. For lactation, it is categorized as L3,which means breast feeding child can be at risk.So it should be avoided.
It can cause lethal effects in newborn such as respiratory depression which can lead to mortality of the newborn. It can also cause hypotonia known as Floppy baby syndrome, in which baby don’t have any tone and feel limp, like a rag doll. It can also cause other symptoms of CNS depression and withdrawal effects even in new born. It can lead to congenital malformations such as cleft palate.
How quickly does treatment work?
Ksalol generally has intermediate onset of action. When administered, it acts within 20-60 minutes.
Is it safe to take Ksalol?
Yes, it’s highly safe to use ksalol due to its wide therapeutic index.
How long does a dose of Ksalol last?
As Ksalol is long acting benzodiazepine so its dose last for 6 hours.
Are there any side effects of the treatment?
Yes, therapeutic doses of ksalol have side effects but these are less likely to be lethal.
Do I require a prescription for taking Ksalol?
Yes, you should have prescription for taking Ksalol because it is only available on prescription by a certified doctor only. This is due to its fatal effects if misused. Having Ksalol without prescription is illegal.
Why is it not safe to buy Ksalol online?
It is not safe because this drug may be fake. FDA strongly discourages consumers from buying online because of the issue of counterfeit. World Health Organization has reported 700 adverse events that have occurred due to consumption of mislabeled Ksalol.
I cannot swallow tablets, what should I take?
You can take Oral Alprazolam liquid. You can also crush or dissolve the tablet in your mouth with water and then swallow .Always use calibrated dropper with this product for accurate dosage
You can also use Alprazolam sublingually.
Is this treatment safe option for children?
Do not give alprazolam to your child without consultation from a health care professional. It is not approved for the treatment of panic attacks in anyone age less than 18 years. For epilepsy, alprazolam can be used. Your child should take alprazolam regularly so that they have fewer seizures. They may also get slurred speech and double vision which usually get better after a week.
How long do I have to take Alprazolam for?
This depends on your medical condition and response to the medication. The doctor may stop the medication to check whether there is improvement in symptoms and whether the medication is still needed. You need to adhere to the directions of your primary care physician cautiously.
Can I take Alprazolam with other medication?
There are certain drugs which shouldn’t be used alongside Alprazolam because some drugs decreases its efficacy and interaction of some drugs wit it ,can cause lethal effects. Severe interaction of Alprazolam can be caused by sodium oxalates.
Serious interactions of Ksalol include:
- Anti-epileptic such as carbamazepine
- erythromycin lactobionate
- erythromycin base
- erythromycin strearate
Ksalol causes moderate interactions with at least 238 different drugs. Concomitant use of opioids and benzodiazepines may result in respiratory depression, severe sedation, soma and death
Can I use Ksalol with alcohol?
No. Combining Ksalol with alcohol is dangerous and can cause respiratory depression (slowed breathing, not getting enough oxygen), extreme sedation, coma, or even death.
Is Alprazolam hard on liver and kidney
Clinically, liver injury from alprazolam is rare. However, it should be used with caution in patients with liver diseases .It is eliminated by kidney; the metabolites can be accumulated in the kidney so it should be cautiously used.
Is it true that Ksalol should not be used in glaucoma?
Yes, it is contraindicated in narrow angle glaucoma.
Is Ksalol a muscle relaxant?
Ksalol is not indicated for use as a muscle relaxant. Valium does have an indication as an adjunct in the relief for skeletal muscle spasms, for patients with muscle spasm due to inflammation; spasticity due to certain conditions such as cerebral palsy or paraplegia; athetosis; and stiff-person syndrome. Occasionally, Ksalol may be used off-label for muscle spasms, but it is not a first-line or common treatment for muscle spasms.