Medication to Kill excessive daytime sleepiness

Excessive daytime sleepiness (EDS) is a state that affects many people worldwide, with varying degrees of severity. Various factors, including sleep apnea, narcolepsy, restless legs syndrome, and others, cause it. The condition is detrimental to the individual affected. It can also be dangerous in certain situations, such as operating heavy machinery or driving.

Fortunately, several medications are available on the market to help combat the symptoms of EDS. This blog post will explore the various medication options available to patients suffering from EDS.


Modafinil is a medication that is commonly used to treat EDS and narcolepsy. It reduces dopamine reuptake in the brain, increasing wakefulness and alertness. This medication is routinely prescribed in dosages ranging from 100 to 400 mg. It typically takes around an hour to produce its effects. Modafinil is considered safe and non-addictive, but users may experience side effects such as headaches, nausea, or nervousness.


Armodafinil is similar to modafinil's action mechanism but is considered more potent and longer-lasting. It is for treating EDS associated with narcolepsy, shift work sleep disorder, or obstructive sleep apnea. The standard dose for armodafinil is 150-250 mg per day, but doctors may adjust the dosage as necessary. Like modafinil, side effects from armodafinil use may include headaches, nausea, and nervousness.


Methylphenidate is a stimulant medication often used to cure attention deficit hyperactivity disorder (ADHD) but can also treat EDS. It increases dopamine levels in the brain, improving wakefulness and alertness. The typical dosage of methylphenidate is around 10-60 mg per day, but doctors will adjust the dosage based on individual needs. Common side effects include trouble sleeping, nervousness, and headaches, but these symptoms usually go away over time.

Sodium oxybate

Sodium oxybate is a central nervous system depressant which is used to treat patients with narcolepsy. It works by decreasing the amount of time spent in REM sleep, which is where most narcolepsy symptoms occur, and it has been proven to help decrease the frequency and severity of EDS. This medication should be taken twice - once before bed and 2.5 to 4 hours later. Sodium oxybate is associated with potential side effects such as dizziness, nausea, headache, and confusion.


Pitolisant is a new medication approved for treating EDS in adult patients with narcolepsy. It enhances histamine activity in the brain, promoting wakefulness and alertness. The standard dosage of pitolisant is generally 17.8 mg, taken once daily upon waking. Common side effects include trouble sleeping, headache, and nausea.


Excessive daytime sleepiness can significantly affect one's quality of life, making everyday tasks difficult to complete and creating safety hazards. Thankfully, there are several medications available to help patients combat this condition. While all medications listed have associated side effects, they are generally well-tolerated and help improve symptoms in patients with EDS. It is essential to consult with your doctor before starting any new EDS medication and report any adverse side effects immediately. Sleep-deprived patients with EDS can regain control of their lives with the right medication and proper care.