Pregabalin
Buy Pregabalin Online
Surfing the internet to buy Pregabalin online, there are certain precautions you have to consider. Don’t worry, chill, and relax. We have made things easy to help you purchase your desired product. We have designed this thorough and detailed medicine guide; based on our vast experience and extensive research. The guide cast light on some of the most common concerns about Pregabalin. It extensively portrays the drug’s safety profile and its benefits. This drug guide will save your time and help you decide whether it is safe to purchase Pregabalin online.
Let’s explore the realm of information!
Pregabalin is an antiepileptic and anxiolytic drug. It belongs to a group of medicine known as anticonvulsants. Pregabalin works by inhibiting chemicals and nerves in the body that cause seizures and some types of nerve pain. It treats and prevents epilepsy (seizures) and generalized anxiety disorder GAD). The drug is also an adjunct therapy with other epilepsy medicines. It treats simple partial-onset seizures (focal onset seizure that begins in one-half of the brain) with or without secondary-generalized seizures. Pregabalin also treats pain due to fibromyalgia, diabetic neuropathy, neuropathic pain (nerve pain) caused by the herpes virus or shingles (herpes zoster) in adults, or spinal cord injury. The drug is also effective for restless legs syndrome (RLS).
Pregabalin was approved in 2004 and developed as a successor to Gabapentin. It has been available as a generic medicine in many countries since 2019. Pregabalin was the 81st most commonly prescribed medication in the United States.
How to Take Pregabalin
Pregabalin is available under different names and in various strengths in the market. It is always best to use Pregabalin only when recommended by your doctor or the pharmacist. Follow the directions carefully on your prescription or read all medication instructions or guides on the leaflet. Pregabalin is an oral medicine; swallow the tablet/capsule whole with a glass of water. Do not chew, crush, and break the tablet/capsule. Try to take Pregabalin at a fixed time each day to obtain the optimal result.
The recommended daily dosage of Pregabalin depends on the type and severity of the symptoms. The course of treatment also depends on your age, weight, and how your body responds to the medication. As a result, the dosage tends to vary from person to person according to the condition for which the doctor has prescribed it. Doctors generally recommend taking Pregabalin three times a day. Be cautious of adverse reactions to Pregabalin in the elderly, like drowsiness, breathing problems, and loss of coordination.
The dosage of Pregabalin depends on the following factors:
- Age
- Type and severity of the symptoms
- The medication strength
- Response to the treatment
- Other pre-existing medical conditions
Try not to miss/skip the recommended daily dosage of Pregabalin. If somehow you missed a dose, take it at once. However, skip the already missed dose if you are due for the next.
How Does Pregabalin Work?
A neurological disorder with abnormal brain activity is called a seizure. Seizures are bursts of uncontrolled electrical activity in the brain that temporarily causes abnormal changes in muscle movements, sensations, or level of awareness. The drug helps decrease the frequency of seizures by slowing down the activity of the central nervous system. It works by helping prevent nerve cells in the brain from sending excessive or inappropriate signals. The drug slows down electrical signals in the brain that cause seizures.
Pregabalin has several modes of action. It interacts with a high-affinity binding site in brain membranes, an auxiliary subunit of voltage-sensitive Ca2+ channels. Pregabalin neither binds to GABA receptors nor influences the synthesis or reuptake of GABA. It stops seizures by inhibiting abnormal electrical activity in the brain. It blocks pain signals by interfering with pain messages traveling through the brain down the spine. It also inhibits the release of anxiety-producing chemicals.
Precautions
Like every prescription drug, Pregabalin has warnings, precautions, and contraindications. It is best to take Pregabalin under the observation of a doctor or physician. Physicians consider the following conditions or circumstances as highly sensitive for the use of Pregabalin:
- Be careful while using Pregabalin without your doctor’s consent.
- It is vital to share your medical history with your doctor if you have pre-existing medical conditions like liver, heart, or kidney problems, high/low blood pressure, lung/breathing problems, chronic obstructive pulmonary disease (COPD), or angioedema, and diabetes.
- Pregabalin may cause severe and life-threatening breathing problems.
- Avoid Pregabalin if you have a history of depression, schizophrenia, or suicidal thoughts. Pregabalin may tend to increase the risk of suicidal thoughts and behavior.
- Avoid alcohol and marijuana (cannabis) while taking the drug. These may make you feel sleepy and cause a hangover; you may lose focus.
- Pregabalin causes blurred vision, sedation, dizziness, or drowsiness. Avoid driving if you are taking this drug.
- There is an increased risk of sedation, accidental falls, and impaired coordination.
- Consult your doctor if you are allergic to Pregabalin or if any allergic reactions appear after using it.
- A pregnant woman should take Pregabalin only if utterly necessary and with a doctor’s consultation.
- A breastfeeding mother should avoid Pregabalin as it passes into breast milk and may potentially harm the nursing baby.
Side Effects of Pregabalin
Like every medicine, Pregabalin has some side effects. These side effects are rare, temporary, and may last for a few days. The most common side effects are nausea, vomiting, diarrhea, abdominal cramps, constipation, dyspepsia, anorexia, flatulence, loss of appetite, muscle tremors, fatigue, taste impairment, involuntary eye movements (nystagmus), diplopia, nervousness, agitation, abnormal gait, lack of muscle coordination, memory impairment, forgetfulness, dry mouth, headache, fatigue, sweating, swelling (on hands, arms, legs, or feet), somnolence, and back pain.
The possible severe side effects are chills and fever, sore throat, infection, bronchitis, nasopharyngitis, peripheral edema, chest pain, irregular heartbeat, increased blood pressure, bruising or unusual bleeding, migraine, slurred speech (dysarthria), blurred vision, tinnitus, sprains, and strains, twitching, vertigo, insomnia/hypersomnia, anemia, urinary incontinence, frequent urination, impotence, erectile dysfunction, depression, anxiety, irritability, aggressive behavior, restlessness, sudden mood swings, panic attack, confusion, convulsions, depersonalization, delusion, hallucinations, and suicidal thoughts or attempts.
Pregabalin may cause some allergic reactions if you are allergic to Pregabalin. The inactive ingredients can also cause allergic reactions. The signs of allergic reactions include skin rash, hives, and itching, wheezing, shortness of breath, trouble breathing or swallowing, asthma, severe dizziness, drowsiness, pruritus, and blistered or peeling skin (Stevens – Johnson syndrome), swelling of the face, mouth, lips, tongue, and throat.
Using Pregabalin to Treat Seizures and Pain
Pregabalin slows down electrical signals in the brain that cause seizures, a neurological disorder with abnormal brain activity. It inhibits the release of anxiety-producing chemicals in the brain. It enables you to sleep better and helps you cope with things or situations that bother you. Pregabalin decreases the frequency of fits and lets you think more clearly, confidently, and positively. It makes you feel less anxious and less fearful; more active and productive in everyday life.
Pregabalin is an anxiolytic and antiepileptic drug. It belongs to a class of drugs known as anticonvulsants. The drug is also an adjunct therapy with other epilepsy medicines. It treats simple partial-onset seizures (focal onset seizure that begins in one-half of the brain) with or without secondary-generalized seizures. Pregabalin also treats pain due to fibromyalgia, diabetic neuropathy, neuropathic pain (nerve pain) caused by the herpes virus or shingles (herpes zoster) in adults, or spinal cord injury.
It is available under a generic name or different trade names in countries with identical effects. The excipients or the shape of the tablet/capsule may vary. The drug helps decrease the frequency of seizures by slowing down the activity of the central nervous system. It works by helping prevent nerve cells in the brain from sending excessive or inappropriate signals.
Pregabalin VS Gabapentin
Pregabalin and Gabapentin have a similar mechanism of action. Both inhibit calcium influx and subsequent release of excitatory neurotransmitters. The drugs differ in their pharmacokinetic and pharmacodynamics characteristics. Pregabalin is absorbed rapidly with maximum plasma concentrations within one hour. Gabapentin is absorbed slowly, with maximum plasma concentration within 3-4 hours. Both drugs are excreted renally with elimination half-lives of approximately 6 hours. Both drugs show the dose-response relationship for postherpetic neuralgia and partial seizures. Pregabalin appears to be more effective than gabapentin for neuropathic pain and seizures.
Pregabalin VS Levetiracetam
Pregabalin and Levetiracetam are effective as adjunctive therapy for partial seizures. Levetiracetam binds to a synaptic vesicle protein, lacks hepatic catabolism (excreted partly unchanged in the urine, and undergoes extra hepatic hydrolysis). It displays therapeutic efficacy within hours. Pregabalin modulates Q-type voltage-sensitive calcium channels. It does not undergo any metabolic transformation and has complete renal excretion. Pregabalin does not have any impact on the hepatic cytochrome system. It is absorbed rapidly and exerts therapeutic efficacy within 48 hours.
Pregabalin is an effective but potentially dangerous drug. It is safe if consumed at the prescribed therapeutic doses. The severity or intensity of the side effects of Pregabalin depends on the amount of the substance intake. Therefore, it is best to consider all the possible side effects and safety warnings before taking the drug. The side effects of Pregabalin are:
Very Common side effects (>10 % of people taking Pregabalin)
Headache, dizziness, drowsiness, sleepiness, confusion, memory impairment, poor coordination, dry mouth, blurred vision, swelling on your hands and feet, and weight gain.
Common side effects (1-10 % of people taking Pregabalin)
Nausea, abdominal cramps, constipation, dyspepsia, anorexia, flatulence, loss of appetite, muscle tremors, fatigue, taste impairment, diplopia, nervousness, abnormal gait, lack of muscle coordination, memory impairment, forgetfulness, dry mouth, fatigue, twitching, swelling (on hands, arms, legs, or feet), rapid weight gain/loss, back pain, fever, infection, bronchitis, nasopharyngitis, peripheral edema, chest pain, irregular heartbeat, bruising or unusual bleeding, migraine, tinnitus, sprains and strains, vertigo, insomnia/hypersomnia, urinary incontinence, frequent urination, impotence, erectile dysfunction, pruritus, anemia, irritability, restlessness, confusion, euphoria, abnormal dreams, depersonalization.
Infrequent side effects (0.1-1 % of people taking Pregabalin)
Depression, anxiety, lethargy, agitation, aggressive behavior, sudden mood swings, panic attack, hallucinations, delusions, nightmares, excessive salivation, tongue edema, involuntary eye movements (nystagmus), sweating, rash, slurred speech (dysarthria), urticaria, dysuria, dysmenorrhea, hematuria, urinary retention, delayed ejaculation, tachycardia, and hypoglycemia.
Rare side effects (<0.1% 0f people taking Pregabalin)
Diarrhea, vomiting, chills, sore throat, cough, fast heartbeat, Hypotension/hypertension, hives, itching, blistered or peeling skin (Steven-Johnson syndrome), swelling or puffiness on the face, eyes, lips, or tongue, unusual tiredness, joint or muscle pain, pancreatitis, convulsions, and suicidal thoughts and behavior.
Pregabalin Interactions
Pregabalin might interact with aspirin, alfentanil, alprazolam, aripiprazole, amoxapine, buprenorphine, cetirizine, citalopram, clozapine, codeine, dezocine, divalproex sodium, estazolam, fentanyl, fluvoxamine, imipramine, ketamine, levorphanol, meperidine, midazolam, phenytoin, vortioxetine, sodium oxybate, tramadol, and zolpidem.
- Pregabalin may cause life-threatening breathing problems like slow breathing with long pauses, blue-colored lips, or fainting. Breathing problems are more likely to happen in older adults or people with COPD.
- People having diabetes must monitor for any new sores or other skin problems.
- Discontinue treatment with Pregabalin if hypersensitivity occurs.
- There is an increased risk of swelling of extremities (peripheral edema), dizziness, drowsiness, blurred vision, and weight gain.
- Pregabalin may have a potential risk of male-mediated teratogenicity.
- Use caution in cardiovascular disease (heart failure) and renal impairment.
- Sudden discontinuation of anticonvulsants abruptly may increase seizure frequency.
- Antiepileptic drugs tend to increase the risk of suicidal thoughts or behavior. Monitor for any new or worsening depression, unusual changes in mood/behavior, and suicidal thoughts or behavior.
- There is an increased risk of life-threatening angioedema with respiratory compromise requiring emergency intervention.
Contraindications
Can I take Pregabalin If I am pregnant?
Take Pregy-50 mg Capsule in pregnancy if utterly necessary and with a doctor’s consultation. There is no evidence of any adverse effects on the neonate.
Can I take Pregabalin if I am breastfeeding?
Doctors generally do not recommend Pregabalin while breastfeeding. The drug passes into breast milk and may adversely affect the nursing baby. The doctor will determine if the potential benefit to the mother justifies the risks to the neonate or nursing baby.
Who should not take Pregabalin?
Avoid Pregabalin if you have pre-existing medical conditions like heart problems, liver or kidney problems, high/low blood pressure, lung/breathing problems, chronic obstructive pulmonary disease (COPD), angioedema, and diabetes.
How long does it take for Pregabalin to work?
Pregabalin has a rapid onset of action and starts working right away in seizures. It may take several weeks to relieve the nerve pain in some people. The drug may take 5-13 weeks for fibromyalgia, diabetic nerve pain, spinal cord injury, and nerve pain.
How long does Pregabalin stay in your system?
Pregabalin typically stays in your blood plasma for about 35 hours. It may be detectable in urine for up to 5-6 days.
Do I require a prescription for taking Pregabalin?
Yes, Pregabalin is a controlled drug. It is a prescription-only medicine.
Is it safe to take Pregabalin?
It is safe to take Pregabalin according to therapeutic parameters. Be extra cautious if you have other pre-existing medical conditions.
Why is it not safe to buy Pregabalin online?
It is not safe to buy Pregabalin online because it’s a prescription-only drug. You have to do thorough research to buy it from a trusted and authentic online vendor.
Is Pregabalin safe for children and elders?
Do not give Pregabalin to children and adolescents under 18 years for nerve pain due to diabetes, fibromyalgia, herpes zoster, or spinal cord injury. Doctors do not recommend it to babies in less than one month for seizures. The lowest effective dose of Pregabalin is best for the elderly. There is a risk of drowsiness, breathing problems, and loss of coordination in the elderly.
Can both men and women use Pregabalin?
Yes, men and women both can use Pregabalin.
For how long can I take Pregabalin?
Take Pregabalin for as long as the doctor has prescribed. The course of treatment depends on the type and severity of the symptoms.
For how often should I take Pregabalin?
You can take Pregabalin three times daily.
Can I discontinue taking Pregabalin if I feel good?
No, it is best to gradually tapper off anticonvulsant drugs. Sudden discontinuation may lead to severe withdrawal symptoms.
Can I use Pregabalin on an empty stomach?
You can take Pregabalin on an empty stomach. However, it may be best to take it with your meal to avoid stomach issues.
Will using Pregabalin affect my ability to drive or work?
Pregabalin causes blurred vision, sedation, dizziness, or drowsiness. Avoid driving if you are taking this drug.
Does Pregabalin become allergic?
Yes, Pregabalin may become allergic if you are allergic to the active ingredient Pregabalin. The inactive ingredients can also cause allergic reactions.
How does Pregabalin manifest its allergies?
Pregabalin may cause allergic reactions like skin rash, hives, itching, wheezing, trouble breathing, severe dizziness, and swelling of the face, mouth, tongue, lips, and throat.
Recap of Pregabalin |A brief sketch
Pregabalin is an antiepileptic and anxiolytic drug. It belongs to a group of medicine known as anticonvulsants. Pregabalin works by inhibiting chemicals and nerves in the body that cause seizures and some types of nerve pain. It treats and prevents epilepsy (seizures) and generalized anxiety disorder GAD). The drug is also an adjunct therapy with other epilepsy medicines. It treats simple partial-onset seizures (focal onset seizure that begins in one-half of the brain) with or without secondary-generalized seizures. Pregabalin also treats pain due to fibromyalgia, diabetic neuropathy, neuropathic pain (nerve pain) caused by the herpes virus or shingles (herpes zoster) in adults, or spinal cord injury. The drug is also effective for restless legs syndrome (RLS).
The recommended daily dosage of Pregabalin depends on the type and severity of the symptoms. The course of treatment also depends on your age, weight, and how your body responds to the medication.
The drug helps decrease the frequency of seizures by slowing down the activity of the central nervous system. It works by helping prevent nerve cells in the brain from sending excessive or inappropriate signals. Pregabalin neither binds to GABA receptors nor influences the synthesis or reuptake of GABA. It stops seizures by inhibiting abnormal electrical activity in the brain. It blocks pain signals by interfering with pain messages traveling through the brain down the spine. It also inhibits the release of anxiety-producing chemicals.
It is best to consider all the possible side effects and safety warnings before taking the drug. The side effects of Pregabalin are headache, dizziness, drowsiness, sleepiness, confusion, memory impairment, poor coordination, dry mouth, blurred vision, swelling on your hands and feet, and weight gain.
Pregabalin may cause life-threatening breathing problems like slow breathing with long pauses, blue-colored lips, or fainting. Breathing problems are more likely to happen in older adults or people with COPD. There is a risk of life-threatening angioedema with respiratory compromise requiring emergency intervention.
Submit your review | |
I started on pregabalin twice a day but have moved to 3 times a day for extreme peripheral neuropathy in both feet. Side effects are minimal and the results are excellent. I can wear shoes now and no longer feel the need to cover my feet at night. Hopefully, this result will last so fingers crossed.